In the past some years the number of products based on new drug delivery system has significantly increased, and this extension is expected to continue in the future. Tablet dosage form is convenient and relevant as compared to other dosage forms. Innovation in tablet dosage form provide product of higher selectivity for the drug for medical treatment. There are so many existing drug delivery technologies in recent years developed. This is an attempt to being made to compile some of the most successfully marketed drug delivery technology in this article. The present review focus on innovation in tablet system i.e. Tablet in tablet system. Evolution of an existing drug molecule from a conventional form in to said technology can improve performance in terms of safety, efficacy and patient compliance.

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Ketoconazole in semisolid dosage forms with chloranil. Method: The method is based on the formation of violet colored complex. The UV spectrum of ketoconazole in methanol and DMSO showed maximum wavelength at 481nm. Beer’s law is valid in the concentration range of 5-30µg/ml. this method was validated for linearity, accuracy, precision, assay, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 5-30µg/ml with the regression equation y = 0.0232x - 0.0015, and regression coefficient i.e. r2 = 0.9991 moreover, the method was found to be highly sensitive with LOD (2.971685µg/ml) and LOQ (0.891506µg/ml). Conclusion: Based on the results the proposed method can be successfully applied for the assay of Ketoconazole in various semisolid dosage forms.

Objective: A new, simple, sensitive, precise and reproducible UV spectroscopic method was developed for the estimation of Imatinib in bulk and solid dosage form. Methods: The UV spectrum of Imatinib showed λ max at 274nm. Beer’s law is valid in the concentration range of 4-20µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 4-20µg/ml with regression equation y = 0.504x + 0.0014and regression correlation coefficient r2= 0.9993. Moreover, the method was found to be highly sensitive with LOD (0.68μg/ml) and LOQ (2.06μg/ml). Conclusion: Depending on results the given method can be successfully applied for assay of Imatinib in Veenat capsule.

Objective: The present study was undertaken to develop a rapid simple specific accurate, precise, robust and economic visible spectrophotometric method for determining the Amorolfine in semisolid dosage form. Method: The Visible spectrophotometric method was performed at maximum wavelength 542nm by using Methanol and DMF as a solvent. The nethod was validated by following the analytical performance parameter suggested by ICH which include accuracy, precision, linearity, robustness, LOD, LOQ and Specificity. Result: The drug obeys the beer’s lamberts law in the concentration range of 10-60µg/ml. It exhibits the good coefficient correlation (0.9992) and excellent mean recovery. The % recovery for precision was found within limit i.e. less than 2% and accuracy gave results within limit i.e. 97-103%. The developed method was suitable and specific to analysis of Amorolfine even in the presence of excipients. Conclusion: The obtained results proved that the validated method can be employed for routine analysis of Amorolfine in bulk as well as in the Cream.

Immunoaffinity chromatography also called immunoadsorption chromatography is a type of affinity chromatography used for the separation of antibodies and identification, purification and quantification of antigens. It is based on the specific interaction of antigen to its antibody. This review discusses the basic components of immunoaffinity chromatography which includes structure, properties, production of antibodies, chromatographic conditions, immobilisation and elution techniques, applications and recent developments of IAC.

Objective: A new, simple, sensitive, precise and reproducible UV spectroscopic method was developed for the estimation of Dapsone in bulk and gel formulation. Methods: The UV spectrum of Dapsone in methanol: water (30:70) showed λ max at 254nm. Beer’s law is valid in the concentration range of 3-15µg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 3-15µg/ml with regression equation y = 0.065x + 0.0353 and regression correlation coefficient r2= 0.9991. Moreover, the method was found to be highly sensitive with LOD (0.519μg/ml) and LOQ (1.729μg/ml). Conclusion: Depending on results the given method can be successfully applied for assay of dapsone in gel formulation.

The aim of the present study was to formulate fast dissolving tablet of Oseltamivir using Superdisintegrants with the help of solid dispersion technique to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Solid dispersion of Oseltamivir was prepared with PVP K30 in different drug: carrier ratio using solvent evaporation methods. The optimized solid dispersion (drug: PVP K30, 1:0.5 ratio) were further used to prepare fast dissolving tablet by direct compression method using superdisintegrants such as Crospovidone and Xanthan gum. Infrared spectroscopy, differential scanning Calorimetry and X-ray Diffraction were performed to identify the physicochemical interaction between drug and optimized formulation. The pre-compression parameter of prepared powder blends all formulation suggested good flowability and compressibility. The prepared tablets were evaluated for thickness, hardness, friability, and weight variation, drug content, wetting time, disintegration time and In vitro dissolution studies. The batch F4- shows highest release of 99.82 % in 30min.

Objective: This study deals with a topical formulations of a alcoholic extract of Tinospora cordifolia and its evaluation. Methods: The dried powdered was extracted with ethanol using Mechanical shaker for 3 hrs. Topical formulation like gel containing ethanolic extract was formulated using gelling agent in different concentration ratio. These gels were evaluated for physic-chemical parameters, viscosity, spreadability, pH and antimicrobial activity. Results: A topical formulation of gel was successfully formulated containing ethanolic of Tinospora cordifolia. The gel shown the effect towards microbial activity. Conclusion: These type of formulations can be provided very effective as a wound healing medicines with ease of use and no side effect.

Objective: A new, easy, non-complex, appropriate and re-performable analytical method was developed for the determination of Salbutamol Sulphate pure drug. Methods: The analysis was performed at λ max 280nm using Di Methyl Formamide (DMF) as blank/diluent. According to International Conference on Harmonization (ICH) the method was validated by the following the analytical performance parameters which included accuracy, precision, linearity, LOD, LOQ, Ruggedness and Robustness. Results: The drug follows the Beer’s Lambert’s law in a concentration range of 10-50µg/ml with regression equation y = 0.0096x-0.0541 and regression co-relation coefficient of 0.9986. However, the method was found to be extreme sensitive with LOD (2.365µg/ml) and LOQ (7.167µg/ml). Conclusion: Depending on results the above method can be performed successfully for the determination of Salbutamol Sulphate pure drug.

In recent years there has been an extensive research on drug development in the various aspects of the diseases like jaundice, hypercholesterolemia and hyperthyroidism. Cholestyramine is a synthetic resin in nature which has been used widely for treatment of same, it is a quaternary ammonium anion exchange resin with a strong affinity for bile salts and tablet dosage form will play a key role in its release and action. Studies also show that this resin is showing anti hyperthyroidism action, therefore based on these results this paper gives a brief application of a tablet dosage form in the treatment of the hyperthyroidism.