Traditional medicines derived from medicinal plants are used by about 60% of the world’s population. This review focuses on Indian herbal drugs and plants used in the treatment of various diseases, especially in India. Phytochemical analysis of extract revealed the presence of flavanoids, steroids, furan, alkaloids, anthraquinone, tannins and saponins but negative result was observed in aqueous extract except tannins. This study showed vital information regarding pharmacological and phytochemical activities of medicinal plants. The Present review article overview the phytochemical and pharmacological properties of medicinal plant and in this article attempt has been made to summarize the anti-inflammatory property of the plant.

Film forming systems can function as both semisolids and patches and can provide topical as well as transdermal delivery as desired. Film Forming Systems creates super saturated systems immediately after application to the skin, overcoming the problem of instability. Thus it improves the drug permeation through skin compared to other dosage forms. The main objective of the present study is to prepare film forming gel of Moxifloxacin Hydrochloride a topical antibiotic agent to improve its delivery across the skin. By changing the concentration of gelling agents a total of 8 formulations were prepared. The prepared film forming gels were evaluated for physical appearance, pH, spreadability co-efficient, drying time, drug content, film properties, stickiness and in-vitro drug release. All the formulations were physically stable with the pH values within the range and have shown good spreadability coefficient. The films were formed within 5mins and were uniform and flexible enough which would not cause discomfort to the patient upon its application. In-vitro diffusion studies were carried out using phosphate buffer pH 6.8 and formulation F4 (Guargum 1%) has shown best results among all the developed formulations.

In this research paper the main aim is formulation and development of Anti-fungal nail lacquer which is used in treatment of onychomycosis. The main aim is formulation and evaluation of Anti-fungal nail lacquer containing miconazole nitrate which is used for the treatment in onychomycosis which is skin disorder cause by the pathogens include dermatophytes, candida and non-dermatophytes. Nail lacquer is also applicable in improvement clinical efficacy and also proper the patients compliance, Preparation of nail lacquer by simple mixing non-volatile, gloss, smoothness to flow, drug diffusion studies drug content compliance. Nail Lacquer is used on fingernail, toenail of the human beings. Which is protect the nail but, nail plate but most significant in maximize the beauty, gloss, impart color. Nail Lacquer is mostly applicable for those drug which have poor bioavailability in oral formulation this techniques is used in maximize the topical bioavailability of drug across the nail. In this formulation used different type of the use in this preparation which is 2 hydroxypropyl beta cyclodextrin, ethylcellulose, nitrocellulose, propylene glycol as well as drug formulate and obtain optimal release conclusion is success in this formulation.

Cyclobenzaprine coordination compound could be a midway acting relaxant, synthetically like amitriptyline coordination compound with higher action. The correct part of activity of muscle relaxant coordination compound that is not to be determined. Be that because it might, it basically acts at the mind stem to decrease tonic physical engine movement, impacting each gamma and alpha engine neurons. Cyclobenzaprine coordination compound could be a white, crystalline antidepressant alkane series salt with the data-based formula C20H21N_HCl and a sub-atomic load of 311.9. It's a liquefying purpose of 217ºC, and a pKa of eight. 47 at 25ºC. It is soluble in water and alcohol freely, meagerly soluble in alcohol, and insoluble in various kinds of solvents of hydrocarbon. If liquid solutions square measure created base-forming, the free base separates. Sustained unharness microspheres of muscle relaxant complex, a striated muscle relaxant that relieves muscle spasm of native origin while not busy with muscle. Muscle relaxant complex is extremely water soluble drug, having low oral bioavailability (33-55%) thanks to in depth metabolism of drug. And also the indefinite quantity forms on the market in market were having trice daily administration. The most objective of gift study was developed to boost oral bioavailability, scale back the frequency of drug administration, and improve patient compliance. During this study, sustained unharness microspheres of muscle relaxant complex was ready by solvent evaporation techniques exploitation Eudragit (EU) RS one hundred, Chitosan and Na alginate as polymers and yield, particle size, encapsulation efficiencies and in vitro unharness of the ready microspheres were evaluated. The results showed that proportion yield, encapsulation efficiencies and particle size were influenced primarily by chemical compound concentration, style of chemical compound and stirring speed. Results of the in vitro study shows that the required rate is achieved by up to twelve hrs. DSC results showing there's no interaction between drug and polymers. SEM results of optimized microspheres showing distinct, spherical microspheres.

Spermacoce latifolia is one of the most important members of medicinal plant belonging to the family Rubiaceae and have a lot of pharmacological properties. A phytochemical study on the roots of the plant Spermacoce latifolia led to the isolation of β-amyrin (1) from the chloroform extract and7-hydroxy-6-methoxycoumarin (2), stigmasteryl-β-D-glucopyranoside (3) and sucrose (4) from the methanol extract. The structure of these compounds has been established on the basis of detailed spectroscopic data analysis including UV, IR, 1D and 2D NMR and Mass. All of these four compounds were isolated from this plant for the first time.

For RP-UPLC method the mobile phase was consisted of methanol, acetonitrile and potassium phosphate buffer at pH 3.0 (40:20: 40 v/v) was selected as a mobile phase which gives good resolution and good peak shapes. The flow rate was set at 0.2ml/min, and the detection was carried out with PDA detector at 233nm. Thermo fisher C18 column (50mm x mm x 3μm), was used for the separation. At the optimum conditions mentioned above. The total run time required was below 5mins. The linearity and range was established over the range 96.072 to 144.048μg/ml of NAC and 8.073 to 12.01μg/ml for CPC. The correlation coefficient of N-Acetyl Cysteine and Clomiphene Citrate was found to be 0.9998 and 0.9999. This method was validated for accuracy, precision, and system suitability. The percentage of recovery of N-Acetyl Cysteine and Clomiphene Citrate was found to be 100.1%, 99.1% for 100% level. The standard deviation values and good recoveries indicate the reproducibility and accuracy of the developed method. As well the Percentage RSD values for precision study also were within acceptable limit.

Plant growth promoting rhizobacteria commonly inhabit rhizosphere of plants and enhance plant growth by exerting beneficial effects through production and release of metabolites. Curcuma longa L is one of important medicinal plant. Useful in boils, bruises, chronic bronchitis, cold cough and coryza, eosinophilia, liver and skin diseases, swellings and wounds of all kinds and dental problems. It Contains curcumin, an alkaloid and an essential oil. The rhizome underground portion of Curcuma longa L is traditionally used as antibacterial substance. Antibacterial substances from plant sources diffuse into surrounding soil area of the plant and inhibit growth of some microorganisms. Among these some microorganisms may produce plant growth promoting substances. Present study is intended to isolate microorganisms from rhizosphere of Curcuma longa L. In the present study total 10 bacterial and 11 actinomycetes isolates were obtained from the rhizosphere soil of Curcuma longa L from Solapur region. These isolates were identified on the basis of morphological, cultural and biochemical characters. All the isolates were screened for their enzymatic potential and plant growth promoting activities (PGP) viz. NH3, HCN, siderophore and IAA production and PO4 solubilization. The results showed that not all isolates possessed all 5 PGP activities. The percentage of NH3, HCN, siderophore and IAA production and PO4 solubilization for bacterial isolates were 100, 70, 30, 100 and 70% respectively and that for actinomycetes isolates were 63.3, 36.36, 36.3, 98.9 and 36.3% respectively. Hence these isolates can be used as sources for plant growth promoting substances and hence are agriculturally important.

A GC-MS/MS method was developed for determination of Epichlorohydrin in Ranolazine drug substance using Rtx-624 column (30m X .32mm X 1.8µm) and a mobile phase of Helium gas with gradient GC oven temperature programming, at flow rate of 1.5ml/min with MS detector. The mass of Epichlorohydrin were found 57, 49 and 62 respectively. The retention time was found 11.4 minutes. The proposed method was validated for System suitability, Specificity, Linearity, LOD and LOQ determination, Recovery, Precision, and Range. All the parameters were found within the acceptable limits. The Linearity of Epichlorohydrin was in the range of 0.155µg/gm to 0.783µg/gm of specification limit. GC-MS/MS method was specific, accurate, precise and suitable for the analysis of Epichlorohydrin in Ranolazine drug substance.

Infertility is one in all the key health problems in life, and approximately half-hour of infertilities are thanks to a male factor. Ginger (Zingiber officinale) has been consumed since antiquity and is thought to play diverse biological roles including anti-oxidation, anti-inflammation, hypolipidemia, anti-carcinogenesis, anti-nausea, antithrombosis, and antibacterial process. Propolis also induces the activation of antioxidant enzymes. This study was designed to analyze the and therefore the therapeutic effects of administration of ginger and propolis individually compared to manage on semen quality of male rabbits. Fifteen mature male rabbits were randomly divided into three groups of 5 rabbits each. Group 1 served as control. However, group 2 got propolis (50mg/kg body weight) and group 3 got ginger (100mg/kg). Animals were orally administered the doses of propolis, ginger daily for 12 weeks. Semen was collected weekly for 12 weeks. Semen quality were evaluated. Results showed that semen quality was increase. Propolis and ginger essentially expanded BW, RTW, testosterone levels and semen characteristics. In spite of the actual fact that both medications had prevalence in comparing with control, most semen characteristics were way better (P<0.05) for propolis than ginger treatment.

An Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method was developed for determination of elemental impurities in Amitriptyline Hydrochloride tablets as per ICH Q3D. New US FDA and EMA regulations came into effect from Jan 2018 as industry standard requirements for the determination of inorganic elemental impurities using ICP-OES or ICP-MS analytical techniques. The method development was optimized for the determination of the class 1 and class 2A elemental impurities listed in ICH Q3. The proposed method was validated for System suitability, Specificity, Linearity, LOD and LOQ determination, Recovery, Precision, and Range. All the parameters were found within the acceptable limits as per ICH Q3D. The Linearity of elemental impurities was in the range of LOQ to 200% of specification level as per ICH Q3D. ICP/MS method was specific, accurate, precise and suitable for the analysis of elemental impurities in Amitriptyline Hydrochloride tablets.