Drug releases from nanoparticles to the site of action and subsequent biodegradation is important for developing a successful formulation. The present work is a prelude in the direction of using Carbon Nanotubes as a vehicle for drug delivery to the desired sites. Release study of the anti cancer drug, Doxorubicin from the functionalized Carbon Nano tubes at different temperature and pH conditions was studied. Loaded anticancer drug shows better release in acidic medium. Moreover, increased release is seen with the increase in temperature.

The aim of this work is to calculate ion-solvent interaction, density of organic-aqueous mixtures of Acetonitrile-water (AN-H2O), density of saturated solutions of oxytetracycline (OTC), salvation volumes (Van der Waals volume VW, molar volume VM and electrostriction volume Ve) and solvated radii (ro) from solubility experiments. It was found that values of the log activity coefficient (γ±) of OTC in (AN-H2O) mixture were decreases by increasing in the content of the organic solvent used. The values of the log (γ±) found to decrease with the increase in temperature. The densities and the molar volumes of the saturated solutions of OTC decrease by increasing ratio of AN and also increases by increasing in temperature. All the electrostriction volumes calculated for OTC having negative values. The electrostriction volumes increase in negativity on increasing the percentages of the organic solvent. The solvated radii of OTC was increased as the organic solvent content increase and as the temperature increase.

A simple and highly efficient process for the synthesis of N, N’ -Diacylhydrazine derivatives containing 2-(2-isopropyl-5-methyl phenoxy) moieties involving stirring of 2-(2-isopropyl-5-methyl phenoxy) N, N’ -Diacylhydrazine derivatives and different benzoyl chlorides at room temperature under solvent free conditions has been described. The synthesized compounds were characterized by MASS, FT-IR, 1H and 13C NMR and were assessed for the antioxidant activity using DPPH assay.

A accurate and precise RP-HPLC method has been developed for the validated of Sofosbuvir and Velpatasvir in bulk and combined Tablet dosage form. Separation was carried out on a Primesil C18 (4.6 x 250mm, 5µm) column using a mixture of Acetonitrile: 0.1% perchloricacid (50:50 v/v) as the mobile phase at a flow rate of 1.2mL/min, The detection was carried out at 262 nm. The retention time of the Sofosbuvir and Velpatasvir 4.25, 5.91 min respectively. The method produce linear responses in the concentration range of 25-150 µg/mL for Velpatasvir, and 100-600µg/ml of Sofosbuvir. The method precision for the determination of assay was below 2.0 %RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

The cause of this Alport syndrome is inherited defect in type IV collagens. Type IV collagen is located or found in the ears, eyes, and kidneys. Alport syndrome affects ears, eyes, kidneys, etc. These descriptions refer to 'classic' Alport syndrome. It found in young adult or late childhood life. Alport syndrome is more severe in men than in women. Alport syndrome is an example of inherited disease that affects the glomeruli. These glomeruli were found in the tiny blood vessels within the kidney. It affects around 1 in 50,000 children. It was characterized by end-stage kidney disease, and hearing loss. This syndrome can also affect the eyes. Angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) should be administered to patients with Alport syndrome. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) classes of drugs apparently help to reduce Proteinuria by decreasing intraglomerular pressure.