1, 5 Benzothaizepines heterocyclic ring system having the diverse pharmacological activities. The present work focus on synthesis of novel Benzothaizepines molecules by condensation of 1- (2', 4'-difluorophenyl) -3- (4"-methyl phenyl) -2-propen-1-one derivatives and O-amino thiophenol in the presence Piperidine and glacial acetic acid. The structures of compounds were confirmed by spectral analysis using IR, 1HNMR and Mass analysis. The biological evolution of compounds was performed for anti-microbial activity by using serial dilution method and cytotoxicity studies by MTT assay method.

Manganese doped Cobalt oxide thin films were deposited on steel substrate by sol-gel spin coat method and investigated the impact of doping on electrochemical behaviour. Cyclic Voltammetry technique was used for the electrochemical characterizations of supercapacitor cells fabricated using the Mn doped Co3O4 thin films as their electrodes. The characterization of the doped electrodes showed a notable effect of the Mn concentration on electrochemical properties and consistently found that with increase in Mn concentration performance of supercapacitor goes on improved, accordingly 1%Mn doped electrode exhibited higher specific capacitance 675F/g at 10mV/s scan rate and good cyclic stability compared to other electrodes with different doping concentrations.

Oral disintegrating tablets have proved to be an alternative to conventional dosage forms, as it has better patient compliance. The FDT’s are solid dosage forms that dissolve or disintegrate rapidly in the oral cavity. This results in solution or suspension without the need of water. The main motive of our work was to formulate and evaluate fast dissolving tablets of aceclofenac coming under the category of NSAIDS. With the help of FTIR studies it was found that aceclofenac was compatible with a wide range of excipients. FDT’s were prepared using different concentration of super disintegrating agent like kollidon CL, kyron T-314, doshion P544-DS by direct compression method and evaluated for hardness, thickness, friability, disintegration time, and percentage of drug release. The results were found satisfactory. Formulation KC2 made of 4% kollidon CL showed highest release rate of 99.31% at the end of 15 min.

Floating system or dynamically controlled systems are low density systems that have sufficiently buoyancy to float over the gastric contents and buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. This system of drug delivery was studied with special focus on the principle mechanism of floatation to achieve gastric retention. For the drugs that gets absorbed in the upper parts of GIT has advantages to formulate as oral sustained release gastro-retentive dosage form. Gastric emptying rate plays important role to develop the dynamically controlled systems. The recent developments of FDDS are approaches to minimize the variability that increase the retention time of drug delivery system for more than 12 hours. This review also includes the summary of various modern in-vitro techniques that shows the proper performance, advantages and applications of floating systems that compiles with the standard limits. Thus FDDS seems to be the promising delivery systems for control release of drugs.

Oral route is most common and convenient route for the administration of drug because of the low cost of therapy and ease of administration lead to high levels of patient compliance as in the form of tablets and capsules. In some cases, the oral solid dosage form may become difficult especially in swallowing (egs: motion sickness, sudden episode of allergic reaction, coughing, fear of choking, unavailability of water, and in different age group of patient and patients who suffer from dysphagia). To overcome these difficulties, fast dissolving drug delivery systems have been developed Fast dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 min when placed in the mouth without water or chewing. These thin sized film stripes are designed in such a manner for ease administration of drug when its placed on or under the tongue. There by the film enables the drug to deliver directly in to the blood stream either buccally or sublingually. Likewise, to improves the onset of action, lower the dosing and enhance the efficacy.