A simple, accurate, precise and sensitive spectroscopic method was developed for the estimation of Labetalol hydrochloride in the pure and tablet dosage forms. The estimation of Labetalol hydrochloride was carried out at the maximum absorbance at 246 nm. The method was found to be linear and obeys beers law in the concentration range 1-10µg/ml with a correlation coefficient 0.999. The developed method was validated as per ICH guidelines and was found to be accurate and precise. Thus the proposed method can be successfully applied for the estimation of labetalol hydrochloride in pure and tablet dosage form.  

Solid lipid nanoparticles (SLNs) are the effective lipid based colloidal carriers which were introduced as an alternative to the conventional carriers such as micro emulsions, liposomes, micro particles and nanoparticles based on synthetic polymers or natural macromolecules. Typically they enhance the oral bioavailability of the low aqueous soluble drugs due to their potential to enhance gastrointestinal solubilization and absorption via selective lymphatic uptake. These properties can be harvested to improve the therapeutic efficacy of the drugs with low bioavailability, as well as to reduce their effective dose requirement. This paper presents an overview about the choice of the drug candidates, advantages, methods of preparation such as high pressure homogenization, ultrasonication/high speed homogenization, solvent evaporation/emulsification, supercritical fluid method, micro emulsion based method and spray drying method are discussed. Appropriate analytical techniques for characterization of solid lipid nanoparticles such as photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry etc. are discussed. Applications with respect of routes of administration such as oral, parenteral, topical, pulmonary etc are elaborated in detail.

The present investigation was undertaken to formulate Deferasirox dispersible tablet for the treatment of chronic iron overload. For the development and formulation of dispersible tablets, wet granulation techniques were carried out. Various approved excipients like cross carmelose sodium and sodium starch glycolate as superdisintegrants, Microcrystalline cellulose pH101 as hydrophilic diluents and sodium lauryl sulphate as surfactant to increase solubility, polyvinyl pyrrolidone as binding agent magnesium stearate and Aerosil as lubricant and glidant were selected. All the experimental formulation batches have been subjected to various evaluation parameters viz, average weight, thickness, hardness, friability, disintegration, uniformity of dispersion, dissolution studies, water content and assay. All the formulations were subjected to physicochemical analysis and out of them Formulation DF4 was found to be satisfactory when compared to other formulations. The disintegration time (30 sec), dispersion time (60 sec) and percentage of drug release (100.08 %) were found to be satisfactory and it matches with the market sample. Finally loaded for stability as per the ICH guidelines.