Endothelial dysfunction and vascular remodelling block tiny pulmonary arteries, resulting in increased pulmonary vascular resistance and pulmonary pressures. This results in a reduction in cardiac output, right heart failure and death. We want to give an explanation in terms of categorization, diagnosis, patho physiology, treatment prognostic variables in this study, which aims to answer some essential concerns often posed by patients diagnosed with pulmonary arterial hypertension. Endothelin-1, reactive oxygen species and endothelial and smooth muscle proliferation are all discussed as key molecular mechanisms in the patho physiology of pulmonary arterial hypertension¹.

Heterocyclic moiety serve as culminate system on which pharmacophores can be successfully joined to deliver novel drugs. Among different heterocyclic compounds, nitrogen-based heterocycles have been broadly explored as they constitute the center structures of various naturally significant atoms and have been found to be dynamic against distinctive sorts of cancers. Due to the flexibility of indole, it has been a profoundly “privileged motif” for the target-based plan and advancement of anticancer specialists. In addition, it has been utilized as a synthon for the arrangement of huge number of bioactive heterocycles and cleared a way to create successful targets. This survey article presents comprehensive diagram of anticancer possibility of differently substituted indole subsidiaries counting 1H-indole-2, 3-dione subsidiaries. Acid-catalyzed, three-component reaction (Biginelli synthesis) between 5-bromo-2, 3-di (furan-2-yl) 1H-indole, acetylacetone and semicarbazide, thiosemicarbazide, urea, thiourea, guanidine constitutes a rapid and facile synthesis of corresponding tetrahydropyrimidines, which are interesting compounds with a potential for pharmaceutical application.

Stannous chloride (SnCl₂) is widely used in daily human life, for example, to conserve soft drink, in food manufacturing and biocial preparations. Animal in this study (ten white rabbits) were divided at random into two equal groups (each group five rabbits). The first group designed to be consider as a control. The second group was created to study the effect of stannous chloride (20mg/kg body weight) for 12 weeks. Overall means indicated that treatment with stannous chloride caused significant (P<0.05) decrease in body weight and relative weight of liver, kidney, spleen, testes, and heart compared to control animals. Additionally, this study indicated that treatment with stannous chloride (SnCl₂) caused significant increase in white blood cells (WBCs) and insignificant decrease in haemoglobin (Hb), red blood cells (RBCs), packed cell volume (PCV) and platelets. The study confirmed the detrimental effects of stannous chloride on the body weight, relative organ weight and hematological parameters on male rabbits.

Garlic (Allium sativum) is an essential vegetable listed in the most top twenty important vegetables, with various uses throughout the world, traditional use as either as raw vegetable for cooking, additionally Garlic play an important role throughout history as a treatment for many disease in traditional and modern medicine. The importance of Garlic and its effect treatment for many disease and disorders comes from that it has richest sources of total phenolic compounds among the usually consumed vegetables, where as highly ranked regarding its contribution of phenolic compounds in human diet. Curcumin, is a major essential compound constituent of turmeric, due to its antioxidant properties and effect, it has a various biological activities. The objective of this study was to evaluate the haematology of rabbits garlic and curcumin supplemented diets using 15 male rabbits garlic (1mg/kg BW) curcumin (40mg/kg BW), were orally administered by gavage alone or in combination. The examined doses were given to rabbits each other day. Results indicated that treatment with garlic and curcumin did not affect red blood cells (RBC), white blood cells (WBC), platelet count (PLT), hemoglobin (Hb), mean cell volume (MCV) and finally the mean cell of hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC). On the other hand increase RBC, WBC, PLT, Aim: The overall aim of this research was to ascertain the comparative of the garlic and curcumin on hematolgical parameters of male rabbits.

Aims and Objectives:  This study on ideal dentist and ideal patient is basically not choosing the best dentist or patient but instead the patient and dentist feedback to emphasize on “Dentist - Patient Relationship”. Materials and Methods: A cross-sectional study was conducted among this feedback jotted out on their opinions straight from the heart. A questionnaire comprising 18 questions on ideal dentist and 12 on ideal patient. The sample size is 500. The perceptions of patients on ideal dentist provided a hand book of easy rules that dentists need not carry' it along but just needed to inculcate it. Results: Habit of tooth brushing was more regular in girls when compared to boys. The most important factors in this research were the mother's socioeconomic background including age, basic education, occupation and attitude towards health education influence the children tooth brushing frequency with oral cleanliness. 76.53% of irregular brushing children and 87.34% of regular brushing children agreed that the brushing of teeth is necessary where as 23.47% of irregularly brushing children and 12.66% of regularly brushing children have disagreed. There was a statistically significant difference was found in the tooth brushing habits and oral hygiene among regularly and irregularly brushing children was 0.0001 and <0.0009. The fluoride consumption of regularly and irregularly brushing children was statistically significant (P<0.00012). Conclusion: Since dentist relies on service to the people, patients mayprefermore importance. Conducting this study does not depend on dentist patient demands but to analyse dentist-patient relationship in the present and to work on the future.

The present research aimed to study some of the physiochemical properties of seawater samples collected in December 2019 from eight beaches about the city of AL-Hudiedah, northern Yemen. The physicochemical properties ranged as follows: temperature (26-27.30°C), pH (7.90-8.33), salinity turbidity (1.5-16 NTU), electrical conductivity (59300-61900 us/ cm), Total dissolved solids (39731-41473mg/L), salinity (37.3-38.4ppt), dissolved oxygen (4.2-7mg/L), biochemical oxygen demand (0.30-2.95mg/L) and Chemical oxygen demand (1300-2300mg/L). The results of the study confirm the importance of protecting AL-Hudiedah coastal waters from several pollutants.

A GC-MS/MS method was developed for determination of N, N-Dimethylaminopropyl chloride (DMPC) in Clomipramine Hydrochloride drug substanceusingDB-624column (30m X 0.25mm X 1.4µm) and a mobile phase of Helium gas with gradient GC oven temperature programming, at flow rate of 1.0ml/min with MS detector. The mass of N, N-Dimethylaminopropyl chloride (DMPC) were found 121, 58 and 42 respectively. The retention time was found 8.5 minutes. The proposed method was validated for System suitability, Specificity, Linearity, LOD and LOQ determination, Recovery, Precision, and Range. All the parameters were found within the acceptable limits. The Linearity of N, N-Dimethylaminopropyl chloride (DMPC) was in the range of 0.026µg/gm (LOQ) to 0.129µg/gm (200%) of specification limit. This GC-MS/MS method was specific, accurate, precise and suitable for the analysis of N, N-Dimethylaminopropyl chloride (DMPC) in Clomipramine Hydrochloride drug substance.

In our present study benzene-1, 2-diamine (1) has been reacted with sodium nitrite in present glacial acetic acid yielded 1H-benzo [d] 1, 2, 3-triazole(2), Which react with 2-chloro-N-phenylacetanide, 2-chloro-N-(4-chlorophenyl) acetamide, methyl 4-(2-chloroacetamido) benzoate, ehtyl4- (2 – chloro acetamido) benzoate, 2-chloro - N - (2-nitrophenyl) acetamide, 2-chloro - N- (4 - nitrophenyl ) acetamide, 2-chloro -N- (3-hydroxy phenyl) acetamide, 2-chloro -N- (p-tolyl)acetamide, 2-chloro-N-(3-nitropheny) acetamide and 2-chloro-N-(4-methoxy-3-nitrophenyl)acetamide to give 2-(1H-benzo [d] 1, 2, 3-triazol-1-yl) -N - (phenyl) acetamide (3) , 2-(1H-benzo [d] 1, 2, 3-triazol-1-yl) - N -( 2-chlorophenyl) acetamide (4), 2-(1H-benzo [d] 1, 2, 3-triazol-1-yl) - N -(4-chlorophenyl) acetamide (5), methyl 4- ( 2- (1H-benzo[d] 1, 2, 3-triazol-1-yl) acetamido) benzoate (6), ethyl 4-(2-(1H-benzo[d] 1, 2, 3-triazol-1-yl) acetamido) benzoate (7). All the synthesized compounds were characterized on the basis of melting point, TLC, IR, ¹HNMR, ¹³CNMR and mass spectrometry.

The present study was carried out to evaluate the diuretic effect of ethanolic extract of Basella alba extract (BAE) in wistar rats and mice by using Lipschitz model respectively. Basella alba extract (BAE) showed significant (p<0.05) diuretic and sedative activity of two doses (100mg/kg and200mg/kg, p.o) tested, when compared to control and drugs furosemide and diazepam respectively. Hence, the Basella alba extract (BAE) possess diuretic activity.

The present study was designed to evaluate the cardioprotective role of Ferulic acid on the in vivo myocardial ischemic reperfusion injury in rats. Methods: Male Wistar albino rats were divided into six groups (n=6). The group C and C-IR animals were administered saline orally (sham, I-R Control group), animals group FA-BL1 and FA-BL2 received ferulic acid 20mg/kg and 40mg/kg b.wt respectively upto 30 days orally without inducing I-R injury and animals group. FA-IR1 and FA-IR2 received FA 20mg/kg and 40mg/kg respectively upto 30 days. On the 30th day animals of C-IR, FA-IR1 and FA-IR2 groups were underwent 15 minutes of ligation of left anterior descending coronary artery and were thereafter reperfused by 60 minutes. Results: In the C- IR group, myocardial infarct size was observed by the presence of unstained necrotic tissue, a significant decrease in the levels of endogenous anti oxidant enzymes (GSH, CAT, SOD), tissue nitrate (NO), cardiac markers (LDH, CK, AST) and increased the lipid peroxidation levels (TBARS) due to the myocardial damage by ischemic reperfusion injury. Chronic oral administration of FA at both doses (20mg/kg and 40mg/kg) significantly restored the myocardial anti oxidant status evidenced by increased SOD, CAT and GSH, tissue nitrate levels, diminished the TBARS levels and prevented the leakage of cardio-specific enzymes LDH, CK, AST. This is further confirmed by histopatholoical changes. Conclusion: Ferulic acid significantly attenuates myocardial ischemic reperfusion injury through augmentation of endogenous antioxidants, stabilization of myocardial membrane permeability and induction of nitric oxide production.