The ligands 1-Amino-2-naphthol-4-sulfonic acid (AANS) and dicyandiamide (DCD) stabilized two binuclear compounds with copper (II) and cobalt (II). AANS suggested bidentate coordination towards metal center in accordance with spectroscopic evidences in both compounds. The acetate group serves as bridge ligand which allowing antiferromagetic and ferromagnetic coupling for cobalt (II) and copper (II). The sulfonic acid presented an unusual behavior. In presence of acetate salt this group did not acts such as Bronsted Lowrry acid neither Lewis base. The coordination was towards amine and alcohol group. This may be due to space availability around metal center in square pyramidal and octahedral geometry.

A reverse phase high performance liquid chromatographic method was developed for the determination of Metformin and Empagliflozin in bulk and Pharmaceutical dosage form. The separation was effected on aC18 column (150 mm x 4.6 mm;5μ)using a mobile phase mixture 50 volumes of methanol and 50 volumes of phosphate buffer in a ratio of40:60 v/v with a flow rate of 1ml/min. The detection was made at 255 nm. Calibration curve was linear over the concentration range of 60-140 μ g/ml of Metformin and 3-7µg/ml of Empagliflozin. The propose method was validated as per the ICH guidelines. The method was accurate, precise, specific and rapid found to be suitable for the quantitative analysis of the drug and Pharmaceutical dosage form.

A simple, accurate and precise reverse phase HPLC method validated for the determination of Ramelteon Tablet dosage form. Chromatography was carried on C18 column using a mixture of PHOSPHATE BUFFER and METHANOL, pH 4.0 (in the ratio 80:20 v/v) as the mobile phase at a flow rate of 1 ml /min with detection at 280 nm by ultraviolet detector i.e. incorporated in HPLC. The retention time of the drug was found to be 5,503 min. The method validation proofs were carried out as per the ICH guidelines. The developed method was validated for linearity over a range of 12μg/ml to 28μg/ml, with a correlation coefficient of 0.998, which shows the method is quite linear. Further precision, ruggedness, accuracy were validated. The %RSD for system precision was observed to be Less Than 2, whereas the method precision was observed to be 0.456. And for ruggedness the observations were found to be 0.5 and 0.4 respectively. The average recovery of 100.0% indicates the capability of the method, and finally no significant differences in % RSD values with respective Retention time prove the robustness of the method. As per ICH guidelines, method validation results are in good agreement. The proposed approach is effective and can be applied for the tablet dosage form estimation of Ramelteon in tablet dosage form.

Parkinson’s disease or Parkinson's sickness (PD) is a degenerative neurological disease. Parkinson’s disease or Parkinson's sickness (PD) is unending, dynamic, neurodegenerative turmoil with an expected predominance of 31 to 328 for every 100,000 individuals around the world. There is no accord with respect to the components and characterization of agony in PD. This paper surveys current information on the conceivable components, characterizations, assessment and potential danger variables for torment in Parkinson’s disease. L-dopa is the backbone of pharmacological treatment for Parkinson’s disease PD; be that as it may, its utilization is constrained by the advancement of engine variances and medication affected dyskinesias. Dopamine agonists (DAs) are additionally utilized, either alone or in mix with L-dopa. The conclusion is for the most part made clinically, despite the fact that up to 25 % of patients with clinical judgments of PD have gotten diverse neurotic findings at dissection.

The term "sustained release" is known to have existed in the medical and pharmaceutical field for many decades. Sustained release dosage forms are designed to release a drug at a predetermined rate by asserting a constant level of drug for a particular period of time with minimal adverse effects. This type of dosage form is possible only with the combination of suitable polymers. Biodegradable materials uses includes in the field of packing, agriculture, medicine and other areas. Now-a-days it has been an increase in interest in biodegradable polymers. Biodegradable polymers can be classified into two classes, synthetic and natural polymers. These are the polymers derived either from the petroleum resources or from biological sources.