Synthesis of Cu(II) complexes with m Metformin were characterized by analytical data, elemental analysis, molar conductance, thermogravimetric analysis. The structural investigation performed by UV spectral technic. Molar conductance values indicate neutral nature of metal complexes. Antimicrobial activity studied at different concentration (MIC method) by disc diffusion technique. The drug metal complexes found to be significant antibacterial and antifungal agents.
A straightforward, practical and economical process for producing quinazolin- 4-(3H)-ones derivatives is describe and a series of derivatives of the 2, 3-di-substituted quinazolin-4-(3H)-ones have been synthesized as a one pot synthesis of the reaction of 2-amino-N-phenyl benzamine and various substituted aromatic aldehyde in the presence of camphor sulfonic acid catalyst in a ethanol as solvent. The final derivatives can be characterized by 1HNMR, 13CNMR and Mass and besides the derivatives examined biological activity. No toxic organic solvents are used in the current procedure. Shortest reaction time, high product yields, easy work-up process and non-chromatographic product purification are only a few of this catalyst's encouraging reaction response characteristics.
Ch. Sudhakar, Anjum Aara, B. V. Durgarao, N. Krishnarao, Shaik Lakshman*.
A simple one-pot multicomponent method that uses Bronsted Acid as a catalyst for methanesulphonic acid for the first time to synthesize a series of dihydropyran (2, 3-c) pyrazole derivatives from ethyl acetoacetate, hydrazine hydrochloride, malononitrile and aryl aldehydes in the presence of methane sulphonic acid. These environmentally friendly multicomponent cyclocondensation methods have a series of intriguing advantages, including the use of a nontoxic solvent, inexpensive and readily available catalyst, simplicity in work-up, high yields (up to 95%) and a green protocol. The compound can be evaluated by 1HNMR, 13CNMR and LCMS. In addition to the evaluated antimicrobial activity.
K. Jagannadham*, P. Manmadha Rao, M. Likitha, B. Lavanya.
In depth study, the synthesis of a series of Schiff bases of (E)-6-(1-(phenyldiamine) ethyl)-9H-carbazol-3-ol derivatives and also exploring biological properties. These derivatives were synthesized by a conventional method from substituted aromatic amines with hetero aromatic amine with compound (3) in the presence of Bronsted acid triflouoro acetic ACD in ethanol as solvent and the compound (3) can be obtained P-benzoquinone with 4-amino acetophenone in the presence copper acetate in CH3CN with strong base such as Cs2CO3 at reflux. All the synthesized analogous were confirmed by spectroscopic method such as 1H NMR and 13CNMR and mass spectral analysis. The structures of the compounds were analyzed by elemental analysis. All derivatives were evaluated against two gram (+Ve) and two gram (-Ve) bacterial strains.
N. Krishnarao*, P. Madhuri, K. D. Prabodh, CH. Jyothi.
The comparative analysis of extract of Bambusa vulgaris young stem and Neolamarckia cadamba root extract’s anti-diabetic properties in STZ-induced diabetic rats.To induce Diabetes, provide a single dosage of 50mg/kg i.p. of STZ dissolved in citrate buffer. EEBV, EENC, AEBV and AENC give as a treated drug dose of 100mg/kg body weight individually. Metformin, the conventional medication, is also taken orally as standard drug in dosages of 10mg/kg of body weight. The full pharmacological treatment regimen took place over the course of 35 day.The result showed that all extracts are significantly decrease blood glucose level.Total phenolic content and total flavonoid content were found higher in ethanolic extract Bambusa vulgaris (EEBV) then ethanolic extract Neolamarckia cadamba (EENC). All extracts are significantly decrease blood glucose level. May be all extracts decreases insulin level in body and career transport GLUT-4 which are insulin dependent transporter and shows significant antidiabetic activity.
Dimpi Dewangan, Neeli Rose Beck*, Ashwani Jangade, Sourabh Ghosh.