Synthesis of Cu(II) complexes with m Metformin were characterized by analytical data, elemental analysis, molar conductance, thermogravimetric analysis. The structural investigation performed by UV spectral technic. Molar conductance values indicate neutral nature of metal complexes. Antimicrobial activity studied at different concentration (MIC method) by disc diffusion technique. The drug metal complexes found to be significant antibacterial and antifungal agents.

A straightforward, practical and economical process for producing quinazolin- 4-(3H)-ones derivatives is describe and a series of derivatives of the 2, 3-di-substituted quinazolin-4-(3H)-ones have been synthesized as a one pot synthesis of the reaction of 2-amino-N-phenyl benzamine and various substituted aromatic aldehyde in the presence of camphor sulfonic acid catalyst in a ethanol as solvent. The final derivatives can be characterized by ¹HNMR, ¹³CNMR and Mass and besides the derivatives examined biological activity. No toxic organic solvents are used in the current procedure. Shortest reaction time, high product yields, easy work-up process and non-chromatographic product purification are only a few of this catalyst's encouraging reaction response characteristics.