Some new series of pyrimidine and its derivatives were synthesized by reacting different substituted 1, 3-diphenyl prop-2-en-1-one (Chalcones) with urea and thiourea in the presence of ethanolic alkali media, the obtained series of compounds i.e. substituted 3, 4-dihydro-4, 6-diphenylpyrimidine-2 (1H)-thione and 3, 4-dihydro-4, 6-diphenyl pyrimidine-2 (1H)-one respectively which are characterized by physical and spectroscopic data. All newly synthesized compounds were evaluated for their antimicrobial activity.

This study has been carried out to know the effectiveness of transdermal patch and gel formulations of venlafaxine in the treatment of depression. In this study different formulations of transdermal patches were formed by using various polymers such as hydroxyl-propyl methyl cellulose (HPMC K4M), ethyl cellulose and eudragit S100 in different ratios. Transdermal gel formulations were also prepared by using polymers such as HPMC K4M and carbopol 930P in order to determine which drug delivery system is effective and serve the purpose best. Results obtained from the evaluation studies of each dosage form revealed that topically applied patch drug dosages forms possess immense potential to control the release rate of medicament to improve the bioavaibility as well as patient compliance as compared to their gel counterparts.

The heterocyclics contains several compound among that thiazole is one amongst the foremost common heterocyclic compound contains an oversized sort of medical specialty activities like anti –oxidant, anti-fungal, anti-malarial, anti-analgesic, anti- inflammatory, anti-cancer and anti-hiv activities. Thiazole and related compounds are called 1, 3-azoles (nitrogen and one other hetero atom in a five-membered ring) Thiazoles metabolized easily and also it is a non-carcinogenic in nature. This abstract aims short review of the already reported article of substituted thiazole throughout past years.

A simple, accurate and precise stability indicating RP HPLC method was develop and validated for the estimation of Guaifenesin in bulk and formulation. The drug and its degradation products formed under various forced degradation conditions were separated on Phenomenex C18 column (250 × 4.6 mm, 5μ) using mobile phase consisting of methanol: Water (60:40% v/v). The flow rate was kept constant at 1.0mL/min and eluents were detected at 230 nm. In forced degradation experiments, guaifenesin was found to degrade in Acid, Alkali, Photolytic and wet heat conditions and was found stable in H2O2 (Oxidative) and dry heat conditions. In calibration curve experiments, linearity was found in concentration range 2-12μg/mL with regression coefficient (R2) 0.999. The equation obtained was y = 102800 x + 24264.

A green thin layer chromatography (TLC) has been developed for the identification and separation of amino acids on silica gel (SG) and cellulose: SG static phases in combination with aqueous solutions of ionic liquids as mobile phase. Better separation efficiency was observed with silica gel as compared to the mixed stationary phase consisting of cellulose with SG. The resolution of three-component mixture (L-lysine + L-glutamic acid + DL-isoleucine) was successfully achieved on silica gel layer using 1% aqueous hexadecyl-trimethyl ammonium-chloride as mobile phase. The proposed method has been successfully applied for identification of L-lysine and L-glutamic acid in Ferseng-vit* syrup, and DL-isoleucine in Zisscovit* syrup.