The present investigate  and an efficient synthesis of a novel derivatives of2-((5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) methyl)-5-phenyl-1, 3, 4-oxadiazole is obtained by the prepared by 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetohydrazide with benzoic acid in the presence of POCl₃. 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetohydrazide is obtained by the mixture of ethyl 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetate with hydrazine in the presence of ethanol. Ethyl 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetate is prepared from -bromo-2-(p-tolyl)-1H-benzo [d] imidazole with bromoester in presence of K2CO3 IH acetone, 5-bromo-2-(p-tolyl)-1H-benzo [d] imidazole can be obtained from 4-bromobenzene-1, 2-diamine with 4-methyl benzaldehyde in the presence of ZrOCl₂.

Celiac disease, often called "celiac sprue," is a chronic inflammatory disorder of small intestinal that arises on exposure to gluten dietary products in susceptible individuals. The chance of getting celiac disease can be raised by a number of conditions, such as diabetes (type 1), Crohn's disease, down syndrome and Addison’s disease. There are a lot of contributing factors to this condition, both environmental and inherited. While the major histocompatibility complex region has been shown to be a genetic predisposition, gluten is an environmental trigger. 1% of people worldwide suffer from celiac disease. The main reason it goes unrecognized is that about half of individuals afflicted don't show the gastrointestinal symptoms instead, they show other indications of deficiency in calories or do not show symptoms at all. In this article, we review the recent data regarding the pathology, clinical indications, available tests for diagnosis, and management of celiac disease by various treatment methods.

Cisplatin is a potent antitumor agent, but its clinical use is limited due to its renaltoxicity. Several pharmacological studies have reported beneficial effects of certain IndianMedicinal plants to protect from kidney and renalinjuries. In the present investigation, theethanolic extract of dried curcuma longa was evaluated for nephroprotective activity in Cisplatin induced renal damage in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of Cisplatin 5mg/kg. Effect of concurrent administration of curcuma longa ethanolic extract at a dose of 250mg/kg given by oral route was determinedusing serum creatinine and blood urea and change in body weight as indicators of kidneydamage. Cystone was used as standard drug. The extract significantly decreased the cisplatin induced nephrotoxicity. Kidney plays a prominent role in the metabolism and excretion of many exogenously administered drugs, diagnostic agents and their metabolites. Nephrotoxins are drugs or chemicals that produce toxic effect on kidney Nephrotoxicity is one of the major side effects of cisplatin. Several studies have shown that cisplatin induces renal damage by free radical generation. Remarkable changes were observed in body weight, serum creatinine and urea levels. It was observed that the ethanolic extract significantly protected the kidneys from injury. Current study results show that the ethanolic extract of curcuma longa is an excellent nephroprotective as compared to cystone.