The present investigate  and an efficient synthesis of a novel derivatives of2-((5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) methyl)-5-phenyl-1, 3, 4-oxadiazole is obtained by the prepared by 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetohydrazide with benzoic acid in the presence of POCl₃. 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetohydrazide is obtained by the mixture of ethyl 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetate with hydrazine in the presence of ethanol. Ethyl 2-(5-bromo-2-(p-tolyl)-1H-benzo [d] imidazol-1-yl) acetate is prepared from -bromo-2-(p-tolyl)-1H-benzo [d] imidazole with bromoester in presence of K2CO3 IH acetone, 5-bromo-2-(p-tolyl)-1H-benzo [d] imidazole can be obtained from 4-bromobenzene-1, 2-diamine with 4-methyl benzaldehyde in the presence of ZrOCl₂.

Celiac disease, often called "celiac sprue," is a chronic inflammatory disorder of small intestinal that arises on exposure to gluten dietary products in susceptible individuals. The chance of getting celiac disease can be raised by a number of conditions, such as diabetes (type 1), Crohn's disease, down syndrome and Addison’s disease. There are a lot of contributing factors to this condition, both environmental and inherited. While the major histocompatibility complex region has been shown to be a genetic predisposition, gluten is an environmental trigger. 1% of people worldwide suffer from celiac disease. The main reason it goes unrecognized is that about half of individuals afflicted don't show the gastrointestinal symptoms instead, they show other indications of deficiency in calories or do not show symptoms at all. In this article, we review the recent data regarding the pathology, clinical indications, available tests for diagnosis, and management of celiac disease by various treatment methods.

Cisplatin is a potent antitumor agent, but its clinical use is limited due to its renaltoxicity. Several pharmacological studies have reported beneficial effects of certain IndianMedicinal plants to protect from kidney and renalinjuries. In the present investigation, theethanolic extract of dried curcuma longa was evaluated for nephroprotective activity in Cisplatin induced renal damage in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of Cisplatin 5mg/kg. Effect of concurrent administration of curcuma longa ethanolic extract at a dose of 250mg/kg given by oral route was determinedusing serum creatinine and blood urea and change in body weight as indicators of kidneydamage. Cystone was used as standard drug. The extract significantly decreased the cisplatin induced nephrotoxicity. Kidney plays a prominent role in the metabolism and excretion of many exogenously administered drugs, diagnostic agents and their metabolites. Nephrotoxins are drugs or chemicals that produce toxic effect on kidney Nephrotoxicity is one of the major side effects of cisplatin. Several studies have shown that cisplatin induces renal damage by free radical generation. Remarkable changes were observed in body weight, serum creatinine and urea levels. It was observed that the ethanolic extract significantly protected the kidneys from injury. Current study results show that the ethanolic extract of curcuma longa is an excellent nephroprotective as compared to cystone.

Objective: To study phytochemicals, determination of total phenol and flavonoid content, antioxidant activity (DPPH Scavenging) and FT-IR spectral analysis in floral parts of Senna surattensis. Methods: The solvents methanol and aqueous are used for extraction of Senna surattensis plant parts. Phytochemical screening of plant parts was carried out in both the solvents. Determination of total phenol content was carried out using Folin - Ciocalteau method and total flavonoid content using Aluminium chloride spectrophotometric method. Antioxidant activity of methanolic extract of plant samples were evaluated with DPPH standard method. The FT-IR is a very useful technique for identifying the functional groups present in the mixture. Results: The result revealed the presence of flavonoids, saponins, Tannins, Triterpenoids, Anthraquinone, Reducing Sugar, Phenolic compound, steroids in methanol and aqueous extract but tannins. Alkaloids were absent in aqueous extract. Total phenol content was expressed in mg of Gallic Acid Equivalent (GAE) per g of dry weight. In results it was found that methanol extract shows highest phenol content 475.94± 0.27mg/g in flowers. The content of flavonoids was expressed in mg of Quercetin Equivalent (QE) per g of dry weight. It was evaluated that total flavonoid content found highest in flowers 465.22± 0.18mg/g in methanol extract.  IC₅₀ for standard ascorbic acid was found to be 51.36µg/ml and for methanol and aqueous extract flower was found to be 68.78µg/ml and 92.73µg/ml respectively. The DPPH radical scavenging activity of Senna surattensis was evaluated and compared with ascorbic acid. The presence inhibition of flowers extract was calculated at various concentration (50, 100, 150, 200, 250 etc.) as well as standard ascorbic acid. The highest scavenging activity of methanolic and aqueous extract were 186.4±0.58% and 138.2±0.58% at concentration of 250µg/ml. The FT-IR spectrum Senna surattensis showed the presence of alkane (C-H), methylene (C-H), (O-H) stretch, (C-N) stretch, (C-O) group, (N-H) stretch, p-directing benzene ring, alkyl halide (C-Cl) and aromatic amine compounds. FT-IR analysis of methanol flower and aqueous extracts of Senna surattensis confirmed the presence of phenols, alcohols, carboxylic acid, amide, aldehydes, ketones, alkanes, alkenes, aromatics, amines and alkyl halides which show major peaks. Conclusion: The results obtained from the preliminary standardization of Senna surattensis are very helpful in the determination of the quality and purity of the crude drug. The refurbished findings of Senna surattensis are promising and further research is important to identify the bioactive compounds, thereby developing nutritional supplements and medications through therapeutic compound isolation.

Objective: The aim of present study was evaluation of anti-inflammatory activity of the various extracts of Ziziphus jujube leaves and barks in animal models by mercury displacement volume method. Materials and methods: Leaves and barks of Ziziphus jujube were powdered, sieved and extracted separately with petroleum ether, chloroform, 90% ethanol and distilled water. Paw edema in animals was produced individually by injecting a 0.1ml volume of formalin into the sub - plantar tissue of the rat hind paw foot. Test drugs petroleum ether extract, chloroform extract, alcoholic extract and aqueous extracts were given orally to all test groups individually at a dose of 200mg/kg according to the body weight. Analgin was used as a standard reference drug. % inhibition produced by Ziziphus jujube leaves and bark extract was comparable with Analgin. Result: The experiment result showed statistically significant anti-inflammatory activity in albino rats against formalin- induced rat paw edema. Study indicates that Ziziphus jujube leaves and bark extract possess significant anti- inflammatory.