A simple approach to the synthesis of acridinediones via one-pot three-component condensation of an aromatic aldehyde, 5, 5-dimethyl-1, 3-cyclohexanedione (dimedone) and p-Toluidine in isopropanol promoted by the use of as an efficient Ammonium molibdate catalyst is described. Excellent yields, catalyst recovery and reusability and easy work-up are attractive features of this green protocol. All the synthesized acridinediones were characterized on the basis of their melting-points, elemental analysis and spectral data such as IR, 1HNMR, 13CNMR and LCMS and the evaluation of antimicrobial activity.
In this study, six new imine compounds (3a-f) were synthesized from 1-naphthyl amine with substituted aromatic aldehydes in EtOH and The catalyst Bronstd acid such as Methanesulphonic acid used as a catalyst and their chemical structures were defined by 1H/13C NMR, IR and elemental analysis studies. Besides, the antimicrobial activity was evaluated by these compounds.
In this investigation, the protocol followed by preparation of a novel derivatives of the desired compounds. The compounds (7a-7f) can be obtained from the mixture of 5-((2-(4-chlorophenyl)-1H-benzo [d] imidazol-1-yl) methyl)-1, 3, 4-thiadiazol-2-amine (5), substituted aromatic carboxylic acid (6) in the presence of dehydrating agent DCC as a catalyst in ethanol at 700C. The compound (5) can be prepared by the mixture of 1-(2-(4-bromophenyl)-5-methyl-1H-benzo [d] imidazol-1-yl)-2-chloroethan-1-one (4) and thiourea in Toluene and con H2SO4. The compound (4) can be synthesized from 2-(4-chlorophenyl)-1H-benzo[d]imidazole (3) with Chloro acetic acid and triethylamine is base and MDC as solvent at 350C. The 2-(4-chlorophenyl)-1H-benzo [d] imidazole (3) is obtained by the 4-Chloro benzaldehyde (2) and O-phenyl diamine (1) in the presence of ZrOCl2in ethanol. All the newly obtained derivatives were evaluated by the advanced spectroscopic analysis such as 1HNMR, 13CNMR and LCMS and structural determination of titled analogous were calculated by elemental analysis. In addition to the newly synthesized compounds were examined by their anti-microbial activity.
In this investigation, the protocol followed by preparation of a novel derivatives of the sniffs base promoted by organic acid catalyst. The compounds.(E)-N-(5-((2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)methyl)-1, 3, 4-thiadiazol-2-yl)-1-phenyl meth animine (7a-7f) can be obtained from the mixture of 5-((2-(4-chlorophenyl)-1H-benzo [d] imidazol-1-yl) methyl)-1, 3, 4-thiadiazol-2-amine (5), substituted aromatic aldehyde (6) in the presence of dehydrating agent camphorsulphonicacid (CSA) as a catalyst in ethanol at 70oC. The compound (5) can be prepared by the mixture of 1-(2-(4-bromophenyl)-5-methyl-1H-benzo[d]imidazol-1-yl)-2-chloroethan-1-one (4) and thiourea in Toluene and con H2SO4. The compound (4) can be synthesized from 2-(4-chlorophenyl)-1H-benzo [d] imidazole (3) with Chloro acetic acid and triethylamine is base and MDC as solvent at 350oC. The 2-(4-chlorophenyl)-1H-benzo [d] imidazole (3) is obtained by the 4-Chloro benzaldehyde (2) and O-phenyl diamine (1) in the presence of ZrOCl2 in ethanol. All the newly obtained derivatives were evaluated by the advanced spectroscopic analysis such as 1HNMR, 13CNMR and LCMS and structural determination of titled analogous were calculated by elemental analysis. In addition to the newly synthesized compounds were examined by their anti-microbial activity.
A great deal of work has been done on the series of six Synthesis of (E)-4-benzylidine-2-(4-(4, 5-diphenyl-1H-imidazol-2-yl) phenyl) oxazole-5(4H)-one (8a-8e) can be obtained by (4-(4, 5-diphenyl-1H-imidazol-2-yl) benzoyl) glycine and aryl aldehyde in the presence of CSA. The compound (6) can be synthesized from compound (4) with glycine. The Synthesis 4-1 H-benzo [d] imidazole-2-yl benzoyl chlorides (5) is obtained by compound (4) with thionyl chloride and 4-(1H-benzimidazol-2-yl) benzoic acid (3) can be prepared from the reaction of benzil with carboxy benzaldehyde, ammonium acetate in the presence of silver triflate. The structures of the compounds were evaluated based on 1H-NMR, 13CNMR and LCMS and by elemental analysis. This compound was screened by anti-bacterial activity.
