The present study was carried out to investigate the phytochemical constituents, in vitro antioxidant potential and anthelmintic activities of Aporosa lindleyana Linn. The dried powdered leaves of Aporosalindleyana Linn were extracted using petroleum ether, chloroform, ethyl acetate and methanol using a soxhlet extractor and preliminary phytochemical screening was performed using standard protocols. All the extract was evaluated for their potential antioxidant activities using test such as DPPH, hydroxyl radical and superoxide anion radical scavenging abilities. Anthelmintic activity of extract in adult Indian earthworm model were screened. Preliminary screening revealed the presence of bioactive compounds especially phenolics, tannins and flavonoids in all extracts. The paralytic (12.34±0.612) and death time (29.20±0.912) of methanolic extract was found to be significant (P<0.05) when compared with paralytic (2.52±0.682) and death time (5.40±0.514) of standard albendazole at 100mg/ml concentration. The results of the present study indicate that the aerial parts of Aporosa lindleyana Linn. exhibited strong anti-oxidant activity and possess significant anthelmintic activity and thus it is a good source of antioxidant and anthelmintic constituents.
Materials whose dimensions are in the nanoscale range that is 100nm or less are called nanomaterials. Their unique size-dependent properties viz. mechanical, electrical and optical properties make these materials superior and indispensable in many areas of human activity including medicine. The use of nanotechnology in the field of medicine could revolutionize the way we detect and treat damages, diseases in the human body in the future and many techniques only imagined a few years ago are making remarkable progress towards becoming realities. Applications of nanotechnology in medicine currently being developed involves employing nanoparticles for drug delivery, for the detection of biological molecules, imaging of diseased tissues and innovative therapeutics. This brief review summarises the most recent developments in the field of applied nanomaterials with respect to the applications in medicine.
A proficient GC-HS method was developed for quantification of Benzene and Mesityl oxide in Rosuvastatin Calcium drug substance with flame ionization detector (FID) using column Rtx-35 Amine (30m length X 0.32mm diameter) 1µm film thickness, Part No: 11354, Make: Restek. Nitrogen is used as Carrier gas at with linear velocity of 19.1cm/sec. The proposed method was validated for System suitability, Specificity, Linearity, LOD and LOQ determination, Recovery, Precision, Range and Robustness. All the parameters were found within the acceptable limits. Linearity of Benzene and Ethylene Dichloride is in the range of LOQ to 150%. The established methodology was commercially useful, specific, accurate, precise and suitable for the analysis of Mesityl oxide in Rosuvastatin Calcium drug substance.
Benzimidazoles are a class of heterocyclic, aromatic compounds which share a fundamental structural characteristic of six-membered benzene fused to five-membered imidazole moiety. Molecules having benzimidazole motifs showed promising application in biological and clinical studies. Benzimidazole and its derivatives having versatile nitrogen containing heterocyclic compounds which have long been known as a promising class of biologically active compounds possessing wide variety of biological and pharmacological activities like antibacterial, anti-inflammatory, anti-ulcer, anti-diabetic etc. Many Scientists have declared that Benzimidazole system possesses the variable sites like position 2 and 5 which can be suitably modified to yield potent therapeutic agents. The present review covers the chemistry and pharmacological activities of substituted benzimidazoles In this research we useFormic acid; Acetyl Chloride; Hydrazine; Benzene-1, 2-diol; Glycolic Acid; Benzoyl Chloride; Methyl Chloride; Ethyl Chloride; Benzamide etc and method is TLC, IRspectra, 1H-NMR and MS.The synthesize compounds were establish to be BA to BK. The compound BA, BC, BJ, BI and BK were established to be the most potent compound through compare to standard drugs phenytoin. Synthesized newer benzimidazole derivatives were screened for Anti-bacterial activity. It was seen that in biological activity; derivatives containing 2-nitro aniline and 3- nitro aniline having significant biological activity than other benzimidazole derivatives.
A fundamental structural feature of benzimidazoles, a group of heterocyclic, aromatic compounds, is the fusion of a six-membered benzene ring with a five-membered imidazole moiety. The use of molecules with benzimidazole motifs in biological and medical research has shown promise. Formic acid, Acetyl chloride, Benzene-1, 2-diol, Glycolic Acid, Benzoyl chloride, Methyl chloride, Ethyl chloride, Benzamide, and other chemicals were utilized in this study. The methods employed were TLC, IR spectra, 1H-NMR, and MS. The disc diffusion method was used to conduct the pharmacological screening for antibacterial activity. It was determined that the synthetic chemicals ranged from AA to AL. When compared to common medicines like Gentamycin, the compounds Benzimidazole (AA), 1-(1H-benzimidazol-2-yl)-2-(3-hydroxyphenyl) ethanone (AC); 2-{3-[2-(1H-benzimidazol-2-yl)-2-oxoethyl] phenyl}-N-phenylacetamide (AJ); 2-{3-[2-(1H-benzimidazol-2-yl)-2-oxoethyl] phenyl}-N-(2-nitrophenyl) acetamide (AK); 2-{3-[2-(1H-benzimidazol-2-yl)-2-oxoethyl] phenyl}-N-(3-nitrophenyl) acetamide (AL) were found to be the most potent.
