The invitro antidiabetic effect of Ethanol extract was prepared from whole plant of Actiniopteris radiata Linn. was evaluated by using chromogenic DNSA method. The Minimum inhibitory concentration was taken to assess antitubercular activity. The results showed that Chloroform extract have more significant Antidiabetic activity as compared to n-hexane, Ethanolic extracts. Pyrazinamide and Streptomycinis taken as standard drugs.

In recent years, considerable attention has been focused on the development of novel drug delivery systems (NDDS). Osmotically controlled drug delivery systems (ODDS) are a type of NDDS which utilize osmotic pressure for controlled delivery of active agent(s). The release of drug(s) from osmotic systems is independent of gastric pH and gastric motility. The release of drug(s) from osmotic systems is affected by various formulation factors such as osmotic pressure of the core component(s), solubility and size of the delivery orifice, and nature of semi permeable membrane. Different types of osmotic systems have been developed implantable and oral. This review preferably focuses on all types of ODDS, formulation of ODDS, factors affecting release of drug and various formulation factors affecting the systems.

In the present work two new, simple, accurate and precise UV Spectrophotometric methods have been developed and validated for the simultaneous estimation of Ubidecarenone and Clomifene Citrate in combined tablet dosage forms. Method –I involves formation and solving the simultaneous equation by using two selected wavelengths 275.0 nm and 296.0 nm, the λ_max of Ubidecarenone and Clomifene Citrate respectively. Method- II is Absorbance ratio/ Q- Analysis method based on the measurement of absorptivity value of two drugs at 282.3 nm (Isoabsorptive point) and 296.0 nm (λ_max of Clomifene Citrate). The Linearity was observed in the range of 12-36 µg/ml and 10-30 µg/ml for Ubidecarenone and Clomifene Citrate respectively. The accuracy and precision of the methods were determined and validated. The percentage recovery of the drugs by the developed method was found to be in the ranges of from 98.0% - 102.8%, that indicates the good accuracy of the method. The developed methods can be used for the routine analysis for the estimation of Ubidecarenone and Clomifene Citrate in pharmaceutical formulations.

Oral dispersible formulation offers a number of advantages in therapeutics. Levofloxacin drug is used in the treatment of a number of infections including infection of Joints and bones, respiratory tract infections, urinary tract infections, skin structural infections and typhoid fever etc. It was used as a model drug to develop a Oral dispersible formulation. In this present study Oral dispersible tablet of Levofloxacin was prepared by using direct compression method and using different superdisintegrants. The Fourier Transform Infrared Spectroscopy study reveals that there is no interaction between the superdisintegrants and drug. The prepared tablets evaluated in terms of their pre-compression parameters, post-compression parameters,in vitro release study. The results conclude that FLOT-7 (96.10%) can be considered as a optimized formula for Oral dispersible tablet of Levofloxacin, when it is compared with other formulation.